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Excalia™ |
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Review
Summary |
Excalia™, by Orexigen Therapeutics, Inc., a neuroscience company, is now called Empatic™, but the product does not seem to have changed. Empatic is thought to “enhance satiety and energy expenditure.”
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| Ingredients At A Glance |
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Empatic is composed of two different drugs: Zonisamide and Bupropion, which are both on the market, though Empatic has not been approved yet, and so is unavailable.
Zonisamide has been used in the U.S. as an anti-seizure medication. Though it is unclear just how Zonisamide works, it is thought that it may possess mechanisms for “sodium-channel modulation and enhancement of dopamine and serotonin neurotransmission,” which latter mechanism could produce feelings of satiety. On its own, Zonisamide has also been shown to produce weight loss in clinical trials, and this may be attributed to its ability, in the hypothalamus, to release Monoamines, which stimulate the POMC neuron while suppressing the NPY/AgRP neuron. This dual function of stimulation and suppression may increase energy and reduce hunger.
Bupropion also works in the hypothalamus by stimulating the POMC neuron, which then releases a hormone that increases energy and reduces hunger.
The combination of Zonisamide and Bupropion works synergistically, according to Orexigen.com, in order to increase energy expenditure and reduce hunger “further than either compound alone.”
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| Costs |
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Empatic is not currently available on the market, as it has not yet been approved.
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| Website In Focus |
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Orexigen.com is an extremely informative site, with animated illustrations of the science behind Empatic. One can learn about the neurons in the hypothalamus, the hormones they secrete, and the interactions of the various drugs Orexigen is testing. For those consumers used to the same old diet website, intent simply on selling a product, Orexigen.com might be a nice break. The site also maintains a thorough account of clinical trials performed.
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| Positives |
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May safely induce weight loss
Clinical trial information available
Animated displays for ease of understanding
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| Negatives |
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Not yet available
Some information on the website is a little “thick” or difficult to understand
Will most likely only be available through prescription
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| Final Thoughts |
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Empatic, formerly Excalia, seems to be an interesting innovation on the weight loss frontier. It is not often that one reads of a drug and how it works. It is refreshing to see a company working hard at producing something substantial and legitimate…this over against the average dietary supplement peddler, who is counting on consumer ignorance and a certain amount of panache when it comes to ingredients. Orexigen, on the other hand, seems genuinely interested in offering a working, tested, and safe product to its future customers. If you are seeking a natural product for weight loss, be sure and choose a product with ingredients that address both aspects of successful dieting. A proven fat-burner is needed to address excess fat on the arms, belly, hips, thighs and buttocks, and a modern appetite suppressant is needed to control caloric intake and help curb cravings. Effective weight loss happens when both dieting needs are addressed. Add a healthy eating plan, and exercise – and you will have success.
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